After your initial communication we request you to provide us your medical, personal, menstrual and obstetric history as well as details of any previous surgeries, previous treatments taken, if any, for assisted reproduction such as previous IVF attempts, surrogacy attempts , laboratory and ultrasonography reports etc. in a prescribed format.
Your reports will be studied in detail and then you will be counselled about the treatment options and various packages of surrogacy, so as to optimize your chances for successful surrogacy treatment. You will be requested to register with our centre.
Once you register with us we will provide you our surrogate’s database and help you choose appropriate surrogate mother.
Now we match your menstrual cycle with that of the surrogate/s-called synchronization of cycles by putting both of you on birth control pills. However, if you do not get periods because your uterus has been removed, the Day 1 of surrogate’s period will be Day 1 of your treatment cycle. Sometimes synchronization may require use of injections- a class of medications called GnRH Analogues, for example-Lupride, Suprefact ,etc. Surrogacy treatment starts from Day 1 ( the day the bleeding starts ) of your cycle.
Now once the cycles are synchronized, you will be stared on certain injections-called Gonadotrophins- to grow and ripen your eggs. This is called “ Controlled Ovarian Stimulation”-because throughout this process of controlled ovarian stimulation, which normally lasts for 9 to 12 days, the response of your ovaries about how many eggs are maturing, will be strictly monitored by periodic transvaginal ultrasonographies,( at our clinic) and sometimes by blood tests. This ensures to optimize your ovarian response and reduce the chances of excessive response. Controlled ovarian stimulation starts from day 1 of your periods.
All the sonographies and blood tests are done at our clinic which means you never have to go elsewhere for these.
We strongly recommend that you be at our clinic from Day 1 of your stimulation, or rather the treatment gets planned only after we know your arrival date in India, ( we have told you to indicate this in your previous information form about your medical and personal data ).
Once you are in India and undergoing stimulation, you will meet our team. All documents will be put in place and the legal and financial aspects will be completed. The Gestational surrogacy agreement will be signed between you and surrogate mother before embryo transfer
Surrogate who is cycled to match your periods, will be begun on her treatment from Day 1 of her period. In case you using Donor eggs or carrying frozen embryos, then cycling is matched and planned accordingly. Surrogate gets medications- Oestrogens and Progesteron- to ripen the inner lining of her uterus-called Endometrium, to become “Receptive” for acceptance and implantation of embryos to be transferred. The response of her uterine lining is periodically assessed using trans-vaginal ultrasound scans at our clinic.
Egg ( Oocyte ) Retreval:
Once the developing egss reach optimum size, the genetic mother or egg donor undergoes procedure of oocyte retrieval, under short General Anesthesia to obtain eggs. IVF/ICSI/IMSI is performed to impregnate these eggs………see ICSI/IMSI Module
Embryo transfer is normally performed on Da2 to Day 5 of embryo formation into well prepared and primed uterus of surrogate mother/s. Surrogate now gets certain medications to optimize implantation of transferred embryos .These medications involve, among others-a group of medications called luteal phase supports.
A test called serum beta hCG IS PERFORMED ON SURROGATE’S BLOOD. ABOUT 14 DAYS AFTER EMBRYO TRANSFER. If the test is positive, the same test is repeated every 4th day till the beta Hcg LEVELS CROSS 20,000iu.
If the wife / female partner is genetic mother , her stay at Kalyan is required for about 18 to 20 days. However, if donor eggs are used then she may even avoid coming to Kalyan, if she so desires. If the Husband is the genetic father , he should be in Kalyan for around 3 days. Fo gay couple, same sex couples and those opting for donor egg or donor embryo, they may come here directly around the time of expected date of confinement of surrogate lady. Frozen embryos can also be shipped to our centre.
What is the overall success rate?
Overall success rate is around 50 to 70% and if you opt for 2 cycle package the success rate climbs up to 75 to 80%.
What happens if surrogate fails to conceive?
In the unfortunate event that the surrogate has not conceived, we stop her medications and let are have period.
If there are any frozen embryos from the IVF treatment, surrogate lady will undergo Frozen Embryo Transfer within two months.
If there are no Frozen Embryos from the first IVF attempt, and you have opted for 2 cycle package you will need to undergo fresh attempt. It is ,therefore, highly recommended that you opt for 2 cycle package as it cuts down on costs and improves success rate.