After the results of tests for egg recipient ( yourself) and egg donor are available, we try to match as closely as possible, your physical and test characteristics with that of the donor. The information we use includes:- Ethnic origin, height, build, skin tone, hair colour, and eye colour. We not only take into consideration the characteristics of female recipient, but, also of those of her partner.
The actual treatment involves synchronization of your menstrual cycle with that of egg donor’s. This involves giving certain medications ( oestrogen and progesterone tablets ) to both recipient and the donor and these medications are stopped at such a point in time frame of treatment ( usually 10 to 20 days ) so that your periods start 1 or 2 days before her period starts. The egg donor will now receive Gonadotrophin injections, ( certain class of drugs ), either by agonist or antagonist protocol, which is so tailored to optimize her eggs ( oocytes) yield. If you are having menstrual periods, you will receive daily Inj. Lupride dose for suppression of your ovaries ( to prevent aberrant endogenous hormones) at the same time you will receive tablets of hormones ( oestrogen ) to cause the growth and ripening of the inner lining of your uterus ( endometrium ) so as that it becomes highly receptive for embryos to be transferred subsequently.
If you have stopped menstruating due to menopause and are no longer having periods, you will just need to take oestrogen tablets without any preliminary treatment.
In the final phase of your endometrial preparation, about 3 days prior to embryo transfer you will receive progesterone treatment ( either Injection or Vaginal pessaries), which is the final step in the preparation of your endometrium to receive embryos.
Egg collection and fertilisation
You will be given an approximate idea of the date that the donor’s egg collection will be performed 2 weeks beforehand but you may only find out the exact date 48 hours before. During this 2 week period you will need to have one or more ultrasound scans to monitor how the lining of your uterus is developing. This information enables us to tailor your response to that of the donor and modify your drug treatment accordingly.
The male partner of the egg recipient is asked to produce a sperm sample on the morning of the egg collection. This would normally need to be produced in the Clinic. The donated eggs are then mixed with or injected with the male partner’s the sperm.( ICSI IMSI ) Fertilisation of the eggs takes place over the next 24 hours and the embryos would normally be ready for transfer to your uterus three days after egg collection.
Embryos are transferred back into the uterus three to five days after the day of egg collection. This is a very important stage of the treatment and the skill with which the embryo transfer is performed is critical in determining the success of the treatment. The embryos transfer is usually a completely painless procedure, similar to having a cervical smear test. A maximum of three embryos can be transferred back into the uterus. The embryos are placed in the middle of the cavity of the uterus and the procedure takes just a few minutes. The embryos do not implant (embed) in the uterus straight away. This only occurs four or five days later but there is no danger of them dropping out of the uterus when you stand up! You can travel back 3 days after the embryo transfer. Thus, the entire treatment takes .
To make the lining of the uterus as receptive as possible to the embryos you will be given progesterone pessaries. These should be commenced the 3days before the egg collection and taken every day until a pregnancy test – serum beta hCG is performed 14 days after the embryo transfer. If you are pregnant, these pessaries will be continued for upto 10 to 12 weeks of pegnancy.
At our clinic the chances of achieving pregnancy by this procedure are around 55 to 60%
Several embryos are usually obtained following treatment and only three of these embryos can be transferred into the uterus. It is therefore possible to freeze some of those embryos, which are not immediately transferred. The decision to freeze the embryos will depend on the number and quality of embryos remaining and if there are a sufficient number of good quality embryos available, these can be frozen and preserved for future use if the current cycle unfortunately fails.
Freezing of extra good quality embryos is done by technique called “ Vitrification. Vitrification is the most advanced method of cryo-preservation by ultra-rapid freezing.” It gives good results, as in this new technique there is hardly any loss of embryos or quality of embryos with regard to it’s implantation potential in the freeze-thaw cycle.