Victoria International IVF Center

(A unit of Ankur Fertility Centre)

Now available in Hebrew and Japanese

After  the  results  of  tests  for  egg  recipient  ( yourself)  and  egg  donor  are  available, we  try  to  match  as  closely  as  possible,  your physical  and  test  characteristics  with  that  of  the  donor. The  information  we  use  includes:- Ethnic  origin, height, build, skin  tone,  hair  colour,  and  eye  colour. We  not  only take  into  consideration  the  characteristics  of  female  recipient, but,  also  of  those  of  her  partner.

Egg Donation Overview

The  actual  treatment  involves  synchronization  of   your  menstrual  cycle  with  that  of  egg  donor’s. This  involves  giving  certain  medications  ( oestrogen  and  progesterone  tablets )  to  both  recipient  and  the  donor  and  these  medications  are  stopped    at  such  a  point  in  time  frame  of  treatment   (  usually  10  to  20  days )  so  that  your  periods  start  1  or  2  days  before  her  period  starts.  The  egg  donor  will  now   receive  Gonadotrophin  injections, ( certain  class  of  drugs ), either  by  agonist  or  antagonist  protocol, which  is  so  tailored  to  optimize  her  eggs   ( oocytes)  yield. If  you  are  having  menstrual  periods,  you  will  receive  daily  Inj. Lupride  dose  for  suppression  of  your  ovaries  (  to  prevent  aberrant  endogenous  hormones)  at  the  same  time  you  will receive  tablets  of  hormones ( oestrogen )  to  cause  the growth  and  ripening  of  the  inner  lining  of  your  uterus  ( endometrium )  so  as  that  it  becomes  highly  receptive  for  embryos  to  be  transferred  subsequently.

 

If you  have  stopped  menstruating  due  to  menopause and  are  no  longer  having  periods, you  will  just  need  to  take  oestrogen  tablets  without  any  preliminary  treatment.

 

In  the  final  phase  of  your  endometrial  preparation,  about  3  days  prior  to  embryo  transfer  you  will  receive  progesterone  treatment ( either  Injection  or Vaginal   pessaries),  which  is  the  final  step  in  the  preparation  of  your  endometrium  to  receive  embryos.

 

Egg collection and fertilisation

You will be given an approximate idea of the date that the donor’s egg collection will be performed 2 weeks beforehand but you may only find out the exact date 48 hours before. During this 2 week period you will need to have one or more ultrasound scans to monitor how the lining of your uterus is developing. This information enables us to tailor your response to that of the donor and modify your drug treatment accordingly.

The male partner of the egg recipient is asked to produce a sperm sample on the morning of the egg collection. This would normally need to be produced in the Clinic. The donated eggs are then mixed with or  injected  with  the  male  partner’s  the sperm.( ICSI IMSI )  Fertilisation of the eggs takes place over the next 24 hours and the embryos would normally be ready for transfer to your uterus three days after egg collection.

 

Embryo transfer

Embryos are transferred back into the uterus three to five days after the day of egg collection. This is a very important stage of the treatment and the skill with which the embryo transfer is performed is critical in  determining  the  success  of  the  treatment. The  embryos  transfer  is  usually  a  completely  painless  procedure,  similar to having a cervical smear test. A maximum of three embryos can be transferred back into the uterus. The embryos are placed in the middle of the cavity of the uterus and the procedure takes just a few minutes. The embryos do not implant (embed) in the uterus straight away. This only occurs four or five days later but there is no danger of them dropping out of the uterus when you stand up! You can travel  back  3  days  after  the  embryo  transfer. Thus,  the  entire  treatment  takes  .
To make the lining of the uterus as receptive as possible to the embryos you will be given progesterone pessaries. These should be commenced the  3days  before the egg collection and taken every day until a pregnancy test – serum  beta  hCG is performed 14 days after the embryo transfer. If you are pregnant, these pessaries will be continued  for  upto  10  to  12  weeks   of  pegnancy.

 

Success  Rate:

At  our  clinic  the  chances  of  achieving  pregnancy  by  this  procedure  are  around  55  to  60%

 

Embryo freezing

 

Several embryos are usually obtained following treatment and only  three of  these  embryos can be transferred into the uterus. It is therefore possible to freeze some of those embryos, which are not immediately transferred. The decision to freeze the embryos will depend on the number and quality of embryos remaining  and if there are a sufficient number of good quality embryos available, these can be frozen and preserved  for  future  use  if  the  current  cycle  unfortunately  fails.

 

Freezing  of  extra  good  quality  embryos  is done  by  technique  called  “ Vitrification.  Vitrification  is  the  most  advanced  method  of  cryo-preservation  by  ultra-rapid  freezing.”  It  gives  good  results,  as  in  this  new  technique  there  is  hardly  any  loss  of  embryos  or  quality  of  embryos  with  regard  to  it’s  implantation  potential  in  the  freeze-thaw  cycle.

IMSI Technique
Intracytoplasmic Mophologically Selected Sperm Injection.In the prevalent ICSI technique,the sperm is magnified 200 times whereas in the IMSI technique the sperm is magnified 7000 times. Only the morphologically normal sperm under this magnification is used for ICSI by our embryologist.

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